MOTS-C
A mitochondrial-derived peptide studied for metabolic health and energy
MOTS-C is a short peptide encoded within mitochondrial DNA. It has been studied in research for its role in energy metabolism, insulin sensitivity, and exercise capacity. Through Madison Meds, MOTS-C is available after a licensed-provider evaluation, with the medication dispensed by a US-licensed compounding pharmacy.
From $179/mo
3-Month $597 ($199/mo) | 6-Month $1,074 ($179/mo) | Available after a licensed-provider evaluation
Frequency
Subcutaneous, per protocol
Rx Required
Yes, Prescribed Online
Pharmacy
US-Registered
Shipping
Free & Discreet
MOTS-C at a Glance
What is MOTS-C? MOTS-C (mitochondrial open reading frame of the 12S rRNA type-c) is a peptide encoded within mitochondrial DNA. It acts as a signaling molecule involved in cellular energy metabolism.
What is MOTS-C used for? In research, MOTS-C has been studied for metabolic regulation, insulin sensitivity, and exercise capacity. It is considered a wellness peptide and is not an approved drug for these uses.
How is MOTS-C taken? MOTS-C is given as a subcutaneous injection on a schedule set by a licensed provider. Dosing is individualized and based on the provider's assessment.
How MOTS-C Works
MOTS-C is a mitochondrial-derived peptide, meaning it is encoded within the DNA of the mitochondria rather than the cell nucleus. Researchers describe it as a signaling molecule that helps coordinate how cells produce and use energy.
Preclinical studies suggest MOTS-C influences the AMPK pathway, a central regulator of cellular energy balance. Through this pathway, it has been studied for its effects on glucose handling, fat metabolism, and the cellular response to physical activity, which is why some researchers describe it as an exercise-mimetic peptide.
Human clinical data remain limited and largely early-stage. MOTS-C is offered as a wellness peptide and may be considered for eligible patients after a licensed-provider evaluation. It is not a substitute for a balanced diet, physical activity, or care from your own physician.
What MOTS-C is studied for
Energy metabolism
Studied in research for its role in how mitochondria generate and regulate cellular energy.
Metabolic support
Preclinical work has examined MOTS-C for glucose handling and insulin sensitivity.
Exercise capacity
Described in research as an exercise-mimetic peptide that may support physical performance and recovery.
Fat metabolism
Explored in laboratory studies for its influence on how the body processes stored fat.
Cellular resilience
Researchers have studied MOTS-C for its role in the cellular stress response and healthy aging pathways.
Longevity-focused
Part of a broader category of wellness peptides studied for metabolic and longevity-related signaling.
What to Expect
Complete your online intake
Answer a short set of health questions so an independent, US-licensed provider can review whether MOTS-C is appropriate for you.
Provider review
A licensed provider from an independent network evaluates your intake and, if appropriate, authorizes a personalized protocol.
Discreet delivery
If eligible, your medication is dispensed by a US-licensed compounding pharmacy and shipped directly to your door with free, discreet shipping.
Compounding Notice
MOTS-C offered through Madison Meds is a compounded preparation prepared by a US-licensed compounding pharmacy. Compounded products are not reviewed by the FDA for safety or effectiveness and are prepared for an individual patient pursuant to a valid prescription. Use only under the ongoing supervision of a licensed healthcare provider. Learn more about compounded medications under section 503A.
Important Safety Information
MOTS-C is considered a wellness peptide and is not an approved drug for metabolic, energy, or performance uses. Research in humans is limited and largely early-stage. Individual results vary.
Do not start MOTS-C without a licensed-provider evaluation. Share your full medical history, current medications, and any history of cancer, diabetes, or metabolic disease with your provider.
Report side effects such as injection-site reactions, unusual fatigue, or changes in blood sugar to your provider. Seek prompt medical attention for any severe or unexpected reaction. This is educational content and not medical advice.
Ready to take the next step?
See whether MOTS-C fits your metabolic and energy goals. Complete a short online intake and a licensed provider will review your eligibility.
FAQ
MOTS-C questions, answered
Educational content. Not medical advice. Individual results vary. Prescription therapies are available only after a licensed-provider evaluation. Medications are dispensed by a US-licensed compounding pharmacy. Talk with a licensed provider before starting or stopping any medication or supplement. See our Compounded Medication Disclosure, Telehealth Disclosure, and Medication Risks.