PT-141
A melanocortin-pathway peptide studied for sexual desire and arousal
PT-141, also known as bremelanotide, is a peptide that acts on melanocortin receptors in the nervous system rather than on blood flow. It has been studied for sexual desire and arousal in both men and women. Through Madison Meds, PT-141 is available after a licensed-provider evaluation, with the medication dispensed by a US-licensed compounding pharmacy.
$225/mo
Monthly (Cancel Anytime) | Available after a licensed-provider evaluation
Frequency
Subcutaneous, as needed
Rx Required
Yes, Prescribed Online
Pharmacy
US-Registered
Shipping
Free & Discreet
PT-141 at a Glance
What is PT-141? PT-141 (bremelanotide) is a synthetic peptide that activates melanocortin receptors in the central nervous system. It has been studied for its effect on sexual desire and arousal.
What is PT-141 used for? PT-141 has been studied for low sexual desire in both men and women. The active ingredient, bremelanotide, is FDA approved under the brand Vyleesi for premenopausal women with acquired hypoactive sexual desire disorder.
How is PT-141 taken? PT-141 is given as a subcutaneous injection on an as-needed basis, typically before anticipated activity. A licensed provider sets your dose and frequency.
How PT-141 Works
PT-141, or bremelanotide, works differently from common erectile medications. Rather than acting on blood vessels, it activates melanocortin receptors in the central nervous system, which are involved in the brain's regulation of sexual desire and arousal.
Because it acts on nervous-system pathways rather than the vascular system, PT-141 has been studied in both men and women. The active ingredient bremelanotide is FDA approved under the brand name Vyleesi for premenopausal women with acquired, generalized hypoactive sexual desire disorder. Compounded PT-141 offered through Madison Meds is a separate compounded preparation and is not the branded product.
PT-141 is typically used on an as-needed basis before anticipated activity. It may be considered for eligible patients after a licensed-provider evaluation. Your provider will review your blood pressure and cardiovascular history, since bremelanotide can transiently raise blood pressure.
What PT-141 is studied for
Central-pathway action
Acts on melanocortin receptors in the nervous system, a different mechanism from blood-flow medications.
Studied for desire
Examined in research for its effect on sexual desire and arousal, not just physical function.
For men and women
Because it works through the nervous system, PT-141 has been studied across both sexes.
As-needed use
Typically used before anticipated activity rather than on a daily schedule.
Non-vascular approach
May be considered for people who prefer an option that does not act primarily on blood vessels.
Provider-directed protocol
Dose and timing are individualized by a licensed provider based on your health profile.
What to Expect
Complete your online intake
Answer a short set of health questions, including blood pressure and cardiovascular history, so an independent, US-licensed provider can review whether PT-141 is appropriate for you.
Provider review
A licensed provider from an independent network evaluates your intake and, if appropriate, authorizes a personalized protocol.
Discreet delivery
If eligible, your medication is dispensed by a US-licensed compounding pharmacy and shipped directly to your door with free, discreet shipping.
Compounding Notice
PT-141 offered through Madison Meds is a compounded preparation prepared by a US-licensed compounding pharmacy. Compounded products are not reviewed by the FDA for safety or effectiveness and are prepared for an individual patient pursuant to a valid prescription. The FDA-approved bremelanotide product Vyleesi is a separate, branded medication. Use only under the ongoing supervision of a licensed healthcare provider. Learn more about compounded medications under section 503A.
Important Safety Information
PT-141 can transiently raise blood pressure and lower heart rate after each dose. It is not appropriate for people with uncontrolled high blood pressure or known cardiovascular disease. Share your full cardiovascular history with your provider.
Common reported effects include nausea, flushing, headache, and injection-site reactions. Do not exceed the dose or frequency your provider sets, and do not use more than one dose within 24 hours unless directed.
Do not start PT-141 without a licensed-provider evaluation. This is educational content and not medical advice. Individual results vary. Seek prompt medical attention for chest pain, severe headache, or any severe reaction.
Ready to take the next step?
See whether PT-141 fits your sexual-wellness goals. Complete a short online intake and a licensed provider will review your eligibility.
FAQ
PT-141 questions, answered
Educational content. Not medical advice. Individual results vary. Prescription therapies are available only after a licensed-provider evaluation. Medications are dispensed by a US-licensed compounding pharmacy. Talk with a licensed provider before starting or stopping any medication or supplement. See our Compounded Medication Disclosure, Telehealth Disclosure, and Medication Risks.